Aiden (a vampire) and Josh (a werewolf), move into a new house together to try and live normal lives. They didn't however know that they would end up with a third supernatural roommate as well. That's when they meet Sally the ghost. The three supernatural creatures go through various adventures together constantly protecting one another like family.

The best private pathologist in Miami, Dr. Beaumont Rosewood, Jr., whose rare heart condition that could kill him at any moment fuels his lust for life, gives a second opinion when friends or family of the deceased are not satisfied with official police findings. His state-of-the-art laboratory equipment, Sherlock Holmes-like powers of deduction and quick wit are his main tools. He also relies and depends on his trusty assistants and cute couple, Pippy and TMI, and works with no-nonsense detective Annalise Villa, who doesn't always go strictly by the book, to see the case to its conclusion.